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Fig. 6 | Biology Direct

Fig. 6

From: Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity

Fig. 6

ISL exerted different effects on cardiomyocytes and cancer cells, and protected mice from doxorubicin-induced cardiotoxicity. A ISL exhibits different effects on H9c2 cardiomyocytes and cancer cells (HeLa and MDA-MB-436). The cell viability was detected by MTT assay after the incubation of cells with different concentrations of ISL with or without 0.5 μM DOX for 24 h. The red dotted line indicates 80% cell viability. Data are plotted as mean ± SD, n = 3, #P < 0.05, ##P < 0.01 when compared with the control group, and **P < 0.01 when compared with the DOX group. B Schematic of the animal experiment. C Representative transmission electron microscopy images of myocardial tissue from control, DOX-treated, and DOX + ISL-treated mice. D Representative echocardiographic images from different groups of mice, with the quantitative results below. Data are plotted as mean ± SD, n = 9 to 11, ##P < 0.01 when compared with the control group; **P < 0.01 when compared with the DOX group. E γ-H2AX was labeled by immunofluorescence staining on paraffin-embedded heart tissue sections

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