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Fig. 2 | Biology Direct

Fig. 2

From: Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice

Fig. 2

Plin5 deficieny impaired insulin signalling in cardiomyocytes. A Expression of AKT, p-AKT, GLUT1, and GLUT4 in wild-type (Plin5+/+) and Plin5-knockout (Plin5−/−) myocardia (n = 3, **P < 0.01, ***P < 0.001). B Expression of AKT and p-AKT in Plin5+/+ and Plin5−/− neonatal mouse cardiomyocytes treated with fatty acids (FAs) (n = 3, *P = 0.05, **P = 0.01). C Immunofluorescence staining of GLUT4 in Plin5+/+ and Plin5−/− neonatal mouse cardiomyocytes and quantification analysis. Scale bar, 10 μm. (n = 3, *P < 0.05). D Expression of GLUT1 and GLUT4 in control (EV) and Plin5-overexpressing H9C2 cells (Plin5) (n = 3, *P < 0.05, **P < 0.01). E Expression of AKT and p-AKT in control and Plin5-overexpressing H9C2 cells (n = 3, *P < 0.05, **P < 0.01). F Immunofluorescence staining of GLUT4 in control and Plin5-overexpressing H9C2 cells and quatification analysis. Scale bar, 10 μm. (n = 3, **P < 0.01)

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