From: Total network controllability analysis discovers explainable drugs for Covid-19 treatment
Host Protein | Viral Protein [Distance] | Host Protein Function | Targeting Drugs (Total number) |
---|---|---|---|
RIPK1 | nsp12 [1] | Inflammation, cell death, pathogen recognition | Fostamatinib |
CYB5R3 | Cholesterol biosynthetic process. | NADH, Flavin adenine dinucleotide, Copper | |
COMT | nsp7 [1] | Neurotransmitter catabolic process | Conjugated estrogens, Diethylstilbestrol, Tolcapone (15) |
SLC10A1 | Bile acid and bile salt transport | Conjugated estrogens, Progesterone, Indomethacin, Cyclosporine A (CsA) (18) | |
SLC10A6 | Transmembrane transport | Pregnenolone, Prasterone sulfate | |
MUC1 | Forming protective mucous barriers on epithelial surfaces | Fostamatinib, Potassium nitrate, TG4010 | |
TTPA | Vitamin E metabolic process | Vitamin E supplements (6) | |
OPRM1 | orf8 [2] | A class of opioid receptors | Tramadol, Morphine, Codeine (47) |
TSPO | orf8 [2] | Steroid hormone synthesis, immune response | Lorazepam, Temazepam, Alprazolam (12) |
GLUL | orf8 [2] | Ammonia and glutamate detoxification, acid-base homeostasis | Pegvisomant, L-Glutamine, Methionine (8) |
IMPDH1 | nsp14 [2] | Regulate cell growth | NADH, Ribavirin, Mycophenolate mofetil (7) |
S100A13 | orf8 [2] | Cell cycle progression and differentiation | Calcium (7) |
RARA | orf8 [2] | Regulation of differentiation of clock genes. | Adapalene, Acitretin, Alitretinoin (7) |
MAPK1 | nsp13 [2] | Differentiation, transcription regulation | Isoprenaline, Arsenic trioxide (6) |
SLC16A2 | nsp7 [2] | Transporter of thyroid hormone | Pyruvic acid, Tyrosine, L-Leucine (6) |
CDK4 | nsp13 [2] | Cell cycle progression | Fostamatinib, Palbociclib, Ribociclib, Abemaciclib |
HDAC4 | nsp13 [2] | Transcriptional regulation, cell cycle progression | Zinc, Romidepsin (4) |
PEF1 | M [2] | Response to calcium ion | Calcium (3) |
CATSPER1 | M [2] | Calcium ion transport | Calcium (3) |
GNMT | orf8 [2] | Methionine metabolic process | Ademetionine, Glycine, Citric acid |
PCYT1A | orf8 [2] | Regulation of phosphatidylcholine biosynthesis. | Choline, Lamivudine, Choline salicylate |
SLC7A1 | nsp7 [2] | Involved in amino acid transport. | L-Lysine, L-Arginine, Ornithine |
YES1 | nsp13 [2] | Innate immune response; transmembrane receptor protein | Fostamatinib, Dasatinib |
ASPH | orf8 [2] | Calcium ion transmembrane transport | Aspartic acid, Succinic acid |
MAT2A | nsp9 [2] | Catalyzes the production of AdoMet | Ademetionine, Methionine |
PCNA | nsp15 [2] | Positive regulation of DNA repair | Liothyronine, Acetylsalicylic acid |
SRR | nsp15 [2] | Catalyzes the synthesis of D-serine from L-serine. | Pyridoxal phosphate, Serine |
SULT2B1 | nsp8 [2] | Catalyze sulfate conjugation of many hormones, and drugs. | Prasterone, Pregnenolone |