Fig. 1
From: Total network controllability analysis discovers explainable drugs for Covid-19 treatment
Control schemes and control hubs of a small network G and a new control-hub-based approach for drug repurposing. (A) Three distinct control schemes are identified by the maximum matching of G. Starting from a driver node (in red), a control path follows matched edges (in red). All control paths form a control scheme for G, and G has three control schemes. (B) G has one control hub node (in green), which appears in the middle of a control path of each control scheme. (C) The study design and the framework of a new control-hub-based approach. A triple-layer network connects the viral and human proteins and drugs and human protein targets. The study focused on the network community of proteins that were no more than two steps away from viral proteins (i.e., the 2-step community) and the 65 druggable control hubs within the community. The enrichment of druggable control hubs within the 2-step community was assessed against several gene ranking methods (see main text)