Fig. 4
From: Discovery biomarker to optimize obeticholic acid treatment for non-alcoholic fatty liver disease
Responder classification based on the Cyp7b1/Cyp8b1 ratio. (A) The expression of bile acid-associated cytochrome P450 genes in the responder group relative to that in the OCA-treated mouse liver tissue. (B) Responder and non-responder classification according to the Cyp7b1/Cyp8b1 ratio. Data are presented as mean ± standard error of mean. *p < 0.05 (Unpaired t-test). (C) Ratio of responder mice among the OCA-treated mice overexpressing cytochrome P450 genes and the response rate according to the Cyp7b1/Cyp8b1 ratio