Fig. 1

Obeticholic acid (OCA) response rates and characteristics of responder and non-responder in the non-alcoholic fatty liver disease (NAFLD) mouse model. (A) Schematic diagram of the study plan. (B) Average bodyweight of mice in the vehicle (n = 8) and OCA-treated groups (n = 19) during drug administration. (C) Liver weight and (D) liver-to-bodyweight ratio (%) of the NAFLD mouse model. Data are presented as mean ± standard error of mean. **p < 0.01 (Unpaired t-test). (E) Response rate in the OCA-treated group. (F) Hematoxylin and eosin staining of liver tissues at pre- and post-treatment. Scale bars, 100 μm. (G) Post-treatment NAFLD activity score. (H) Post-treatment bodyweight, liver weight, and liver-to-body weight ratio (%) of mice in the vehicle (n = 8), non-responder (n = 12), and responder (n = 7) groups. (I) Serum levels of alanine aminotransferase and (J) total cholesterol. Data are presented as mean ± standard error of mean. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 (one-way analysis of variance)