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Table 2 The trend of literature coverage for S. cerevisiae genes in various FPE score thresholds

From: Did the early full genome sequencing of yeast boost gene function discovery?

FPE score threshold

Phase 1—moderate growth

Phase 2—accelerated growth

Phase 3—decline

Slope

R2

P-value

Years

Slope

R2

P-value

Years

Slope

R2

P-value

Years

T0

3.58

0.73

1.03E−07

1965–1989 ↑

24.35

0.87

2.77E−04

1989–1997 ↑↑

−12.31

0.94

1.96E−15

1997–2021 ↓

T1

2.69

0.85

1.12E−10

1965–1989 ↑

7.90

0.83

3.95E−05

1989–2000 ↑↑

−3.65

0.62

1.30E−05

2000–2021 ↓

T5

2.69

0.89

1.02E−15

1975–2005 ↑

10.17

0.86

3.01E−04

2005–2013 ↑↑

−4.20

0.40

6.73E−02

2013–2021 ↓

T10

1.78

0.90

2.55E−14

1980–2007 ↑

2.72

0.48

4.27E−03

2007–2021 ↑↑

–

–

–

–

T15

1.13

0.83

1.32E−11

1980–2007 ↑

2.65

0.51

2.78E−03

2007–2021 ↑↑

–

–

–

–

T20

0.88

0.88

2.84E−13

1980–2007 ↑

3.14

0.60

6.49E−04

2007–2021 ↑↑

–

 

–

–

T25

0.70

0.79

2.70E−10

1980–2007 ↑

2.38

0.79

9.49E−06

2007–2021 ↑↑

–

–

–

–

T30

0.54

0.82

4.29E−11

1980–2007 ↑

2.51

0.82

3.44E−06

2007–2021 ↑↑

 

–

–

–

T35

0.47

0.76

1.83E−09

1980–2007 ↑

2.45

0.76

2.17E−05

2007–2021 ↑↑

–

–

–

–

T40

1.86

0.91

8.33E−12

2000–2021 ↑

–

–

–

–

–

–

–

–

T45

1.63

0.91

5.39E−12

2000–2021 ↑

–

–

–

–

–

–

–

–

T50

1.40

0.81

1.09E−08

2000–2021 ↑

–

–

–

–

–

–

–

–

T75

0.98

0.75

2.09E−07

2000–2021 ↑

–

–

–

–

–

–

–

–

T100

0.83

0.85

7.91E−10

2000–2021 ↑

–

–

–

–

–

–

–

–

T500

0.09

0.51

1.87E−04

2000–2021 ↑

–

–

–

–

–

–

–

–

  1. The letter “T” in abbreviations “T0, T1, etc.” means “threshold” that is applied to FPE values (see ranges in first column of Table 1). The dependency of the number of new genes in the respective FPE range as a function of the year is analyzed with linear regression methods. We omitted 2022 from this analysis because of the extremely small numbers, an artifact that might be caused due to COVID-19 restrictions. The trend of changes is generally identified through three phases, i. e. Phase 1, Phase 2 and Phase 3. The slopes, R2 and P-value in time intervals are listed based on linear regression model yi ~ C + b.xi; where yi is the total number of new genes reaching the specific FPE threshold at year i; xi is the year i; b is the slope and C is intercept. A dash “- “ denotes not enough data. The slope (b) indicates the rate increase/decrease of the total number of new genes reaching a specific FPE score threshold throughout the years. A positive slope indicates that, as a trend, the total number of new genes reaching a specific FPE score threshold tends to be larger than in the previous year (or from year to year); a negative slope indicates otherwise. R2 is the square of correlation ρ or the goodness of fit of the linear regression. P-value is the statistical significance of the slope. The total number of genes reaching the specific FPE score threshold can then be estimated by: Ni ~ N(i−1) + yi; where Ni and N(i−1) are the total number of genes reaching the specific FPE score threshold at year i and (i−1) respectively
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