Fig. 5

Blocking ILC1s promoting the tumor growth of MC38 tumor-bearing mice by inhibiting the M1-like phenotype macrophage polarization. A–C The tumor graph, tumor weight, and tumor volume in ILC1s mice and control mice, n = 5. D Representative flow cytometry graphs of getting the tumor tissue macrophage. E CD86 MFI of M1-like phenotype macrophage (CD45⁺F4/80⁺CD86⁺) in the tumor of ILC1s-blocking mice and control mice was detected by flow cytometry, n = 5. F CD206 MFI of M2-like phenotype macrophage (CD45⁺F4/80⁺CD206⁺) in the tumor of ILC1s mice and control mice was detected by flow cytometry, n = 5. G Western blotting was used to detect the expression of iNOS and Arg-1 in the tumor of ILC1s mice and control mice. H Representative flow cytometry graphs of getting the tumor tissue ILC1s in different groups. I Relative number of ILC1s in different groups, n = 5. J Representative flow cytometry graphs of getting the tumor tissue IFN-γ in different groups. K The expression level of IFN-γ in the tumor of ILC1s mice and control mice, n = 5. All the experiments repeated for 3 times. Data are shown as mean ± SD (n = 5 per group, *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001)