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Fig. 2 | Biology Direct

Fig. 2

From: USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice

Fig. 2

The effects of Runx2 depletion on the expression of ADAMTS genes in NP-1 cells treated with or without LPS

The Control-KD1/2 and Runx2-KD1/2 cells in the NP-1 background were treated with or without 20 ng/mL LPS for 6 h, followed by RNA isolation and RT-qPCR analyses to examine the mRNA levels of Runx2 and ADAMTS genes. (A)Runx2, ADAMTS1, -2, -3, -4, -5, -6, -7, -8, and − 9. (B)ADAMTS10, -12, -13, -14, -15, -16, -17, -18, -19, and − 20. *P < 0.05; **P < 0.01; ***P < 0.001; ns: no significant difference

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Biology Direct

ISSN: 1745-6150

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