Fig. 6
From: Pro-tumorigenic role of lnc-ZNF30-3 as a sponge counteracting miR-145-5p in prostate cancer
Inhibition of miR-145-5p in lnc-ZNF30-3 depleted PC3a cells rescues cell migration and TWIST1 expression levels. A. Images of cell monolayers and quantification of wound healing in PC3a cells 24Â h post-scratch transfected with siSCR or siLNC together with control (CTR-IN) or miR-145 inhibitor (miR-145-IN). B. Western blot and quantification of TWIST1 and ZEB1 protein levels in PC3a cells transfected with siSCR or siLNC together with scramble (CTR-IN) or miR-145 inhibitors (miR-145-IN). C. Model for miR-145-5p, lnc-ZNF30-3 and TWIST1 crosstalk in regulation of EMT properties of PC3a cells that can contribute to cancer progression and dissemination.