Skip to main content
Fig. 1 | Biology Direct

Fig. 1

From: ANKRD29, as a new prognostic and immunological biomarker of non–small cell lung cancer, inhibits cell growth and migration by regulating MAPK signaling pathway

Fig. 1

Establishment of risk-score system. A Volcano plot of differentially expressed genes (DEGs) using TCGA-NSCLC datasets. B The Venn diagram of the overlapping genes of DEGs and 75 ANKRD genes. C Cross-validation for parameter selection in the LASSO regression model. D Coefficient profiles for the LASSO model. E Risk score and survival time, and heatmap of the five ANKRD genes in the TCGA database. F Kaplan-Meier curves were performed to estimate the OS time in the high-risk and low-risk groups of NSCLC patients. G Time-dependent ROC curve for predicting 1-, 3-, and 5- year survival. H Nomogram for predicting 1-, 3-, and 5- year OS of NSCLC patients. I Calibration curve for the OS nomogram model in NSCLC patients. J-M Relationship between clinicopathological characteristics and risk scores based on the five ANKRD genes. The distribution of risk scores showed statistically significant differences in NSCLC patients stratified by WHO stage (J), T stage (K), N stage (L) and primary therapy outcome (M). ROC: receiver operating characteristic; OS: overall survival. Bars are the mean value ± SD. ns = no significant. * P < 0.05, ** P < 0.01, *** P < 0.001

Back to article page

Biology Direct

ISSN: 1745-6150

Contact us