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Fig. 5 | Biology Direct

Fig. 5

From: LncRNA RP11-620J15.3 promotes HCC cell proliferation and metastasis by targeting miR-326/GPI to enhance glycolysis

Fig. 5

RP11-620J15.3 directly binds to miR-326 and negatively regulates the miR-326 expression. A Bioinformatics analysis of the potential target genes was performed by using prediction software (such as mirdb, lncbase, tarbase, and targetscan). B The target miRNA expression in HCC tumors and non-tumor tissues in the TCGA database. C qRT-PCR results showed the miR-326 expression in RP11-620J15.3 overexpressing or knockdown HCC cells. D Pearson’s correlational analysis of RP11-620J15.3 and miR-326 in 80 HCC tissue samples. E Schematic diagram of the potential binding site between RP11-620J15.3 and miR-326. F Dual luciferase reporter gene detection confirmed the interaction between RP11-620J15.3 and miR-326. *p < 0.05, **p < 0.01, ***p < 0.001

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Biology Direct

ISSN: 1745-6150

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