Fig. 3

M2 macrophage-derived exosomal miR-193b-3p enhances the proliferation, migration, invasion, and glutamine uptake of SW1990 cells. Effect of exosomes derived from M0 macrophages (M0-exo) or M2 macrophages transfected with the miR-193b-3p inhibitor (M2/Inhibitor-exo) or NC (M2/NC-exo) on the A, B proliferation (scale bar: 50 μm), C, D migration, E, F invasion, G glutamine uptake, and H miR-193b-3p expression of SW1990 cells (n = 3 per group). Effect of M0-exo, M2/Inhibitor-exo, or M2/NC-exo on I, J lung metastasis in mice (scale bar: 200 μm) (n = 5 per group). Data are expressed as mean ± SD (n = 3 or 5). ***P < 0.001 versus M0-exo. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 versus M2/NC-exo.