Modification | Duplex stability | Hybridization specificity | Sensitivity to pH changes | Sensitivity to ionic strength | Solubility | RNAse resistance | RNAse H activation |
---|---|---|---|---|---|---|---|
PNA | ↓ | ↑ | ↓ | ↓ | ↓ | ↑ | ↓ |
LNA | ↑ | ↑ | ↓ | ↓ | ↓ | ↑ | ↓ |
PSO | ↓ | N/A | N/A | N/A | ↓ | ↑ | N/A |
MOE, 2’-O-Me | ↑ | N/A | N/A | N/A | ↑ | ↑ | N/A |
2’-F,2’-deoxy | ↑ | N/A | N/A | N/A | ↑ | ↑ | N/A |
Triazole-linked | ↓ | N/A | N/A | N/A | N/A | ↑ | N/A |