SBS best match | Aetiology | Cosine similarity | |
---|---|---|---|
HM | |||
Signature 1 | SBS44 | Defective DNA mismatch repair | 0.81 |
Signature 2 | SBS10b | Polymerase epsilon exonuclease domain mutations | 0.78 |
Signature 3 | SBS6 | Defective DNA mismatch repair | 0.90 |
HM-like | |||
Signature 1 | SBS1 | Spontaneous or enzymatic deamination of 5-methylcytosine | 0.94 |
Signature 2 | SBS30 | Deficiency in base excision repair due to inactivating mutations in NTHL1 | 0.83 |
Signature 3 | SBS6 | Defective DNA mismatch repair | 0.93 |
Non-HM | |||
Signature 1 | SBS1 | Spontaneous or enzymatic deamination of 5-methylcytosine | 0.96 |
Signature 2 | SBS40 | Unknown | 0.89 |
Signature 3 | SBS6 | Defective DNA mismatch repair | 0.77 |