Adaptive multiscapes: an up-to-date metaphor to visualize molecular adaptation

Biology Direct

Table 1 Some quantitative properties of the map from RNA sequences to secondary structures at two different temperatures

Phenotype	Size at 37 °C	Size at 43 °C	\(p_{\text {stay}}^{37}\)	\(p_{\text {stay}}^{43}\)	\(p_{\text {stay}}^{37 \to 43}\)	\(p_{\text {stay}}^{43 \to 37}\)
(((...))).	6935	4307	0.3961	0.3872	0.6209	0.9998
(((....)))	7791	5149	0.3864	0.3658	0.6585	0.9963
((....))..	7766	5879	0.5142	0.4915	0.7550	0.9973
((.....)).	4802	2692	0.4431	0.4137	0.5539	0.9881
((......))	1438	1	0.4092	0	0.0007	1
.(((...)))	2287	1542	0.3843	0.3661	0.6707	0.9948
.((....)).	5718	3624	0.4470	0.3996	0.6338	1
.((.....))	944	0	0.3684	–	0	–
..((....))	1729	360	0.3861	0.2928	0.2076	0.9972

The non-empty phenotypes are listed in the first column, while the second and the third columns yield the size of the phenotype
in two different environments (at two different folding temperatures, 37 °C and 43 °C); \(p_{\text {stay}}^{37}\) and \(p_{\text {stay}}^{43}\) are the probabilities that
a point mutation does not change the phenotype at 37 °C or 43 °C, respectively; \(p_{\text {stay}}^{37 \to 43}\) is the probability that a given sequence
folds in the same phenotype when the temperature changes from 37 °C to 43 °C, and similarly for \(p_{\text {stay}}^{43 \to 37}\)

ISSN: 1745-6150