Numerical simulation of vascular tumour growth under antiangiogenic treatment: addressing the paradigm of single-agent bevacizumab therapy with the use of experimental data

Table 4 Parameter values that have been specified by locally fitting the vascular tumour growth model to experimental data extracted from [60]

Study	Experimental group	λ ₁	c	d	β	p	K ₀	RMSE	FOO
		day⁻¹	mg/day · mm^3p · kg	day⁻¹ · mm⁻²	mm^3p	-	mm³	mm³
Dataset 1	Control	4.7129	0.1519	0.0015	-	-	159.4476	10.7552	3.31 · 10⁻²
	Treatment	0.6701	0.0991	0.0015	1	4.0606	76.0920	7.0026	1.5 · 10⁻³
	(5 mg/kg)	0.6701	0.0991	0.0015	1	4.0606	76.0920	7.0026	1.5 · 10⁻³
Dataset 2	Control	0.1340	1.1503	0.0088	-	-	650	13.3087	1.12 · 10⁻²
	Treatment	0.1049	0.5236	0.0088	1.4456	3.8916	358.2054	11.7711	6.72 · 10⁻⁵
	(5 mg/kg)	0.1049	0.5236	0.0088	1.4456	3.8916	358.2054	11.7711	6.72 · 10⁻⁵

First-order optimality (FOO) is a measure of the closeness of the solution to the optimum

ISSN: 1745-6150