Figure 1

C14 miRNAs target the glioma pathway. The biological process has been drawn by adapting the information from the KEGG pathway. mRNA names are written in dark grey boxes. The miRNAs targeting the corresponding genes are denoted by numbers and written inside circles. The miRNAs that were found to be significantly downregulated in GBM (Figure 2) has been colored in green, the ones not differentially expressed are in grey. The miRNAs are numbered according to their respective positions (5’ – 3’ direction) in the genome: hsa-miR-379 (1), -299-3p (2), -380 (3), -1197 (4), -323-3p (5), -323-5p (6), -323b (7), -758 (8), -329 (9), -543 (10), -495 (11), -654-3p (12), -654-5p (13), -376-a1 (14), -376-a2 (15), -539 (16), -382 (17), -134 (18), -668 (19), -485-3p (20), -485-5p (21), -377 (22), -541 (23), -409-3p (24), -409-5p (25), -412 (26).