Somatic transposition in the brain has the potential to influence the biosynthesis of metabolites involved in Parkinson’s disease and schizophrenia

Table 1 The list of diseases of the central nervous system (CNS) that can be linked to metabolites influenced by TE insertions

Nr.	Disease	Expected	SD	Observed	P	Metabolites
1	Parkinson’s disease	2.318	1.734	7	0.004	3-Methoxytyramine,Dopamine,Fe2+, Homovanillate,Phenethylamine,Serotonin, Taurine
2	Alzheimer’s disease	6.539	1.433	8	0.244	3,4-Dihydroxy-L-phenylalanine, L-3-Amino-isobutanoate,L-Cystathionine, Dopamine,Fe2+,Succinate,L-Tyrosine, 24-Hydroxycholesterol
3	Schizophrenia	2.447	1.257	5	0.040	4-Hydroxyphenylacetate,Dopamine, Homovanillate,Taurine,L-Tyrosine
4	Canavan disease	2.967	1.104	4	0.338	Oxidized glutathione,Reduced glutathione, Orotate,Succinate
5	Autism	0.156	0.377	2	0.005	L-Cystathionine,Homovanillate
6	Epilepsy	3.156	1.184	4	0.376	4-Hydroxyphenylacetate,Homovanillate, Taurine,L-Tyrosine
7	Friedreich’s ataxia	0.222	0.443	1	0.210	Homovanillate
8	Major depressive disorder	0.636	0.589	2	0.057	Homovanillate,Serotonin
9	Multiple sclerosis	3.458	1.489	5	0.224	Cholesterol,Fe2+,Oxidized glutathione, Reduced glutathione,24-Hydroxycholesterol
10	Hypothyroidism	3.100	1.484	6	0.027	Dopamine,Homovanillate,Serotonin, L-Thyroxine,Triiodothyronine,L-Tyrosine

The expected numbers of such metabolites (+/− SD), and P were estimated by Monte Carlo simulations, which show how many such metabolites would be expected if the same number of TE insertions as observed by Baillie et al. (16) were distributed across the genes of the human metabolic network randomly. Hypothyroidism is also included, because it shares metabolites with several diseases of the CNS, like dopamine, serotonin, homovanillate or L-Tyrosine.

ISSN: 1745-6150