Figure 4

Selective nuclear transport segregates the cytoplasm and nucleoplasm. The geometry used for the simulations has a closed NE (A). Transport via NPCs is defined as fluxes across the NE. (B) Steady state distribution of RanGTP, RanGDP, karyopherin and karyopherin-RanGTP along the line shown in panel (A). (C) Steady state distribution of host-RP, mitochondrial-RP, karyopherin-host-RP and karyopherin-mitochondrial-RP complexes along the line shown in panel (A). (D) Chimerism (mitochondrial-RP/host-RP) at different values of the forward rate constant for the mitochondrial-RP, karyopherin-RanGTP exchange reaction (mitochondrial-RP + karyopherin-RanGTP => mitochondrial-RP-karyopherin + RanGTP) along the line shown in panel (A). The grey curve (NE 20:1) is the same as the red curve on Figure 3H (NE 20:1), and is shown for comparison.