From: Transposable element derived DNaseI-hypersensitive sites in the human genome
Cluster 1 | Name 2 | Accn 3 | Description 4 | HS site 5 | TE 6 |
---|---|---|---|---|---|
2 | CD97 | NM_078481 | leukocyte antigen; receptor involved in both cell adhesion and signalling processes early after leukocyte activation | 12460_5 | SINE/MIR/MIR |
2 | IGLC2 | BC073786 | Ig light-chain, partial Ke-Oz- polypeptide, C-term; immunoglobulin lambda constant region 2 | 13851_3 | LTR/ERVL/LTR16A |
2 | IGLC1 | BC070353 | constant region of lambda light chains | 13851_3 | LTR/ERVL/LTR16A |
2 | MR1 | CR602405 | major histocompatibility complex, class I-related | 1311_2 | LINE/L2/L2 |
2 | ADORA2A | NM_000675 | adenosine receptor subtype A2a; G-protein coupled receptor; reduces the activation status of inflammatory cells | 13875_2 | SINE/MIR/MIR3 |
2 | CKLF | NM_016951 | chemokine-like factor (cytokine); essential role in the immune and inflammatory responses; potent chemoattractant for neutrophils, monocytes and lymphocytes | 10591_2 | SINE/Alu/AluSg |
2 | KLF6 | NM_001008490 | Kruppel-like factor 6; core promoter guanine-rich element binding protein; transcriptional activator | 6794_2 | SINE/MIR/MIRb |
2 | IL16 | CR749286 | interleukin 16; lymphocyte chemoattractant factor; cytokine; modulator of T cell activation; mediated by CD4 | 10023_2 | DNA/MER1/MER117 |
2 | ST6GAL1 | NM_173216 | sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); role in T-cell death; generation of cell-surface carbohydrate determinants and differentiation antigens | 3308_3 | SINE/MIR/MIR3 |
2 | HLA-E | NM_005516 | HLA class I histocompatibility lymphocyte antigen, E alpha chain; immunoregulatory role for cytotoxic T-lymphocytes | 4584_2 | DNA/MER1/Charlie1 |
2 | IL21R | NM_181078 | interleukin 21 receptor; type I cytokine receptor; transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells | 10408_3 | SINE/MIR/MIRb |
2 | ITGB2 | NM_000211 | leukocyte cell surface adhesion glycoprotein; complement receptor C3 beta-subunit; integrin beta 2; macrophage antigen 1; facilitates inflammatory cell recruitment | 13756_2 | LINE/L1/LIME4a |
2 | FYB | NM_001465 | FYN-binding protein; adhesion and degranulation-promoting adaptor protein; adaptor helps form immunological synapse between T cell and antigen-presenting cell; mediates signaling from the T cell antigen receptor to integrins | 3896_2 | SINE/MIR/MIR3 |
2 | IGHG1 | BC024289 | immunoglobulin heavy constant region gamma 1; involved in antigen binding and immune response | 9667_2 | LINE/L1/L1 |
2 | PTPRC | Y00062 | protein tyrosine phosphatase receptor; leukocyte-common CD45 antigen; essential regulator of T- and B-cell antigen receptor signaling; regulator of cytokine receptor signaling; involved in hematopoiesis | 1347_2 | LINE/L1/L1ME |
2 | LCP2 | NM_005565 | lymphocyte cytosolic protein 2; adaptor or scaffold protein that promotes T cell development and activation as well as mast cell and platelet function. | 4315_2 | SINE/Alu/AluSx |
2 | CD53 | NM_000560 | glycoprotein leukocyte cell surface antigen; contributes to the transduction of CD2-generated signals in T cells and natural killer cells; role in T cell growth regulation | 964_2 | LINE/L2/L2 |
2 | DOCK2 | NM_004946 | dedicator of cytokinesis 2; hematopoietic cell-specific CDM family protein essential for lymphocyte chemotaxis; mediates T cell receptor-induced activation of Rac2 and IL-2 | 4313_2 | SINE/Alu/AluSx SINE/MIR/MIR |
2 | CD74 | BC024272 | cell surface antigen; major histocompatibility complex, class II invariant chain; involved in NF-kappaB activation and interleukin-8 production | 4254_2 | DNA/MER1/Charlie8 |
2 | MX1 | NM_002462 | myxovirus resistance protein 1; interferon inducible; role in host defense against viruses | 13686_3 | DNA/MER1/MER5A |
25 | CD6 | U66145 | glycoprotein cell surface antigen; involved in lymphocyte activation and thymocyte development; role in maturation of the immunological synapse | DNA/MER1/MER113 | |
25 | PLA2G4B | NM_005090 | phospholipase enzyme secreted by neutrophils; produces arachidonic acid used for the biosynthesis of leukotriene in inflammatory response | 9758_2 | SINE/MIR/MIRb SINE/Alu/AluY |
25 | BCL2 | NM_000633 | B-cell lymphoma protein 2; blocks the apoptotic death of some cells such as lymphocytes | 12021_2 | LINE/L1/HAL1 |
25 | TRA@ | BC063432 | T cell antigen receptor alpha locus; involved in thymocyte developement | 9169_2 9171_2 9174_4 | LINE/L1/L1ME2 SINE/MIR/MIR LINE/L2/L2 |
25 | CCR9 | NM_031200 | chemokine (C-C motif) G protein coupled receptor; regulator of thymocytes migration and maturation in normal and inflammation conditions; functional specialization of immune responses in different segments of the gastrointestinal tract | 2827_2 | LINE/L1/L1ME4a |
25 | TCF7 | NM_003202 | T cell specific transcription factor; regulates T cell development and peripheral T cell differentiation | 4139_4 | LINE/CR1/L3 |
25 | CCL5 | NM_002985 | T cell specific chemokine (C-C motif) ligand; chemoattractant for blood monocytes, memory T helper cells and eosinophils; causes release of histamine from basophils and activates eosinophils; | 11206_2 | LINE/L1/L1MB3 |
25 | LAT | NM_001014987 | linker for activation of T cells; phosphorylated following activation of the T-cell antigen receptor signal transduction pathway; acts as a docking site and recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes | 10425_2 | SINE/Alu/AluJb SINE/MIR/MIR |